Inherent Interfacial Mechanical Gradients in 3D Hydrogels Influence Tumor Cell Behaviors
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منابع مشابه
Inherent Interfacial Mechanical Gradients in 3D Hydrogels Influence Tumor Cell Behaviors
Cells sense and respond to the rigidity of their microenvironment by altering their morphology and migration behavior. To examine this response, hydrogels with a range of moduli or mechanical gradients have been developed. Here, we show that edge effects inherent in hydrogels supported on rigid substrates also influence cell behavior. A Matrigel hydrogel was supported on a rigid glass substrate...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2012
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0035852